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October 30, 2015

New treatment for deadliest brain cancer available at UVA

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A device that represents a rare advance against glioblastoma – the deadliest form of brain cancer – is now available to newly diagnosed patients after successful testing at the UVA Cancer Center and more than 80 other sites around the world.

The federal Food and Drug Administration has approved the use of the device, called Optune, in newly diagnosed patients after it was shown to extend patients’ survival by approximately three months compared with standard radiation and chemotherapy treatment alone. Optune previously had been approved for use in patients with recurrent glioblastoma, or patients whose glioblastoma had progressed after radiation and chemotherapy.

The device consists of four electrode pads that attach to the scalp, powered by a small portable battery or by plugging it into an electrical outlet. It emits low-level, alternating electrical fields called “tumor-treatment fields.” Patients wear the device night and day.

David Schiff, MD, co-director of the UVA Neuro-Oncology Center, spearheaded UVA’s testing of the device. “Novel approaches are needed against these very aggressive tumors, and the data from laboratory testing suggested very low intensity electrical fields could halt malignant cells from dividing with a favorable safety profile,” he said.

Clinical trial findings

The international clinical trial of the device looked at 695 newly diagnosed patients, comparing the outcomes of those who following radiation received standard treatment with the chemotherapy drug temozolomide alone with the outcomes of patients who wore the device while receiving the drug. Patients who used the device saw their disease progression halt for an average of about seven months, compared with four months for those receiving only the drug. Overall survival for wearers of the device was 19.4 months after starting treatment, compared with 16.6 months for those who did not wear the device, the FDA reported.

The most commonly reported side effect of the Optune device was skin irritation. However, Optune should not be used by patients who have an implanted medical device, skull defect or sensitivity to conductive hydrogels, such as used during electrocardiograms.

Patients interested in exploring Optune as a treatment option should contact the UVA Neuro-Oncology Center at 434.982.4467.



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